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To minimize the computation, two procedures are presented: the first one is an iterative exploration of the linkage group, the second a reduction of this group within bounds specific of the tested position x.
Complementary to the algorithm presented by Nettleblad and colleagues (2009), it limits the exploration of the linkage group to the markers really informative for a given position to be traced, and thus performs faster.
Exploration of the linkage disequilibrium (LD) pattern surrounding SNP rs681524 (in a 1-Mb window surrounding rs681524) was made using data from the 1000 Genomes Project (23) using the SNP Annotation and Proxy Search tool (24) and the TwinsUK cohort whole-genome sequencing sample as part of the UK10K project.
Innovative methods of disseminating learning and change to the wider primary care environment are also required, while exploration of the linkage between SEA and improving the engagement of GP teams in local or national patient safety reporting systems should also be elucidated.
The establishment of SID-Cymru and exploration of the linkage methodologies will improve our understanding of those who complete suicide (particularly those not known to mental health services) and will be used to inform service planning and policy decision making and implementation.
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A realist case study design was chosen to allow for an in-depth exploration of the linkages between context, intervention, mechanisms and outcomes as they happen in their natural setting.
As a seminal exploration of the linkages between QOL and preferred environmental and ecosystem features, the present study explicitly posed the hypothesis that those exhibiting high QOL are more likely to describe their domicile as providing access to restorative environments defined by specific components of the landscape.
These associations may lead to a different, and potentially more comprehensive, perspective on the pathogenesis of HNSCC, and support further exploration of mechanistic linkage and, if so, novel therapeutic strategies such as demethylating agents and probiotic adjuncts, particularly for patients with advanced or refractory disease.
17 An exploration of the extent to which these linkage strategies and enablers are present in a network provides a description of network function, capacity and areas for improvement, particularly through the use of a continuous cycle of evaluation feedback.
We anticipate that further mechanistic exploration of the underlying mechanisms for these linkages will lead to the discovery of novel therapeutic targets of T2D and other metabolic disorders.
The strength of the study is the development of a retrospective cohort with high overall linkage rates in a national population; the exploration of the potential role of socio-economic variables and country of birth available in the Census; and the linkage of Census data to both cancer registry and community/hospital mortality data.
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