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Although exploration of the genome has already begun, it will be decades before every detail is thoroughly known.
HR uses homologous sequences for repair, but how homology search, the exploration of the genome for homologous DNA sequences, is conducted in the nucleus remains poorly understood.
The sequencing of polyA-neutral RNA enables a less biased transcriptional exploration of the genome.
Phenotype driven genetic screens allow unbiased exploration of the genome to discover new biological regulators.
Additionally, we developed our own software tools to facilitate exploration of the genome and comparison of the three annotations.
Similarly, genomes for other model species were sequenced and online interactive databases were created to allow exploration of the genome sequences, genetic data and annotations for the species (2 7).
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Here we present an exploration of the genomes of 12 fungi, the S. scitamineum plus other 11 fungi, and identify members of the G protein-coupled receptor family from the entire deduced proteomes.
The often-employed strategy of transcriptome sequencing for exploration of the genomes of non-model organisms can produce a wealth of information for comparative and functional genomics studies due to high coverage of the gene space and provide the necessary information for marker development, including single nucleotide polymorphisms [ 3].
We expect that further exploration of the genomes of other ctenophores, early branching metazoans, and closely related non-metazoans will help determine the exact point in evolutionary history at which both canonical and mirtron-based miRNA pathways (and their components) emerged.
Additionally, an integrative genome browser serves as a main entrance point for the exploration of the moss genome and annotation.
In order to facilitate the full use of this genomic resource there has been an extensive exploration of the rat genome with a focus on gene finding.
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