Exploration of alternative structures of the substituted piperidine or piperazine ring which are characteristic in most of the reported GPR119 agonists provided novel spirocyclic cyclohexane derivatives.
Further exploration of the reactivity of the substituted ring system has included metal-catalyzed cross-coupling reactions between 1,2,4-triazoles and other aromatic systems, radical alkylation, addition of perfluorinated ponytails, and asymmetric synthesis of aminoacids.
Through our exploration of family physicians' conflict with substitute decision-makers, we developed a cohesive, practical approach that could assist clinicians with finding Common Ground with surrogates when providing care to dying patients.
In a remarkable exploration of his personal desires, which he substitutes for data, he fits right in with the Freudians and fetish systematizers who have been marginalized and limited to ever smaller circles in the scientific community.
But that is no substitute for the exploration of relationships.
Design, synthesis, processing, and testing, or perhaps better altogether exploration, of biomaterials, which are intended to substitute native tissue, have generally been approached from one of two distinct perspectives.
While it's useful to read competitive benchmark reports, there is no substitute for hands-on exploration of vendor programs.
But this stirring and funny novel, with its compelling exploration of Britishness, loyalty and personal sacrifice, makes an entirely credible substitute for the facts.
We tested the credibility and significance of digital field photographs as supplements or substitutes for conventional herbarium specimens with particular relevance to exploration of the tropics.
Highly scripted lessons don't just handcuff teachers; they cheat students -- especially poor and minority students -- by substituting a diet of isolated skills for the thoughtful exploration of ideas.
