Sentence examples for exploration of sequence from inspiring English sources
Successful design methods should allow the exploration of sequence space not found in nature.
Therefore, construction and testing of random domain insertion libraries, in which a host protein domain is randomly inserted into a guest protein domain, significantly benefit extensive exploration of sequence spaces for insertion sites.
Low mutation rates preclude the exhaustive exploration of sequence space for protein evolution and genome engineering applications, prompting scientists to develop methods for efficient and targeted diversification of nucleic acid sequences.
The progress achieved by several groups in the field of computational protein design shows that successful design methods include two major features: efficient algorithms to deal with the combinatorial exploration of sequence space and optimal energy functions to rank sequences according to their fitness for the given fold.
In principle, CPD can easily generate hundreds of thousands of sequences for a single backbone template, potentially improving the exploration of sequence space in cases where experimental data is rare.
DOI: http://dx.doi.org/10.7554/eLife.11282.015 Figure 4B offers an alternative perspective on the exploration of sequence space by the HIV-1 populations.
ESG recursively performs PSI-BLAST searches from sequence hits obtained in the initial search from the target sequence, thereby performing multi-level exploration of the sequence similarity space around the target protein.
The quantitative nature of flow cytometry makes it an ideal tool for the exploration of protein sequence space and for the evolution of new function.
Many variants were carried forward and continuing evolutionary pressure drove de novo exploration of the sequence space.
The exploration of the sequence space in search of improved phenotypes is a collective process.
We hypothesized that a similar exploration of DNA sequence combinations could be used for controlling the morphology of nanomaterials.
