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The duration for novel object exploration compared to the familiar object was also significantly increased in both the short- and long-term memory (all t 9) < −6.190, p < 0.01) in animals with vmPFC HFS prior to the NOR testing.
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Mice with prior exposure to the novel object showed more object exploration compared to object-naı̈ve mice on day 3.
Only 31.5% of women are in favour of shale gas exploration compared to 58% of men.
In our model JS rats exhibited reduced novel-setting exploration compared to Naïve and JS+EE rats.
Post-hoc analysis revealed that juvenile NHL rats (1.05±0.06 sec, n = 6) spent significantly shorter time on object exploration compared to CTR rats (1.68±0.05 sec, n = 6; P<0.001 for NHL vs. CTR; Fig. 4f, h).
In rats, post-natal maternal separation resulted in increased object exploration compared to controls (Hensleigh et al., 2011; Roy and Chapillon, 2004).
This arose because of decreased novel object exploration compared to saline after both low (sal vs. 0.4 mg/kg p<0.05) and high doses (sal vs. 0.8 mg/kg p<0.05) of SKF81297.
Note: HFS (100 Hz) at 200 μA and LFS (10 Hz) at 50, 200, 400 μA significantly increased the novel object exploration as compared to the sham animals, respectively.
Successful novel object recognition is indexed by greater exploration of the novel compared to the familiar object.
The novel object exploration was also higher compared to the familiar object (t 9) = −14.636, p < 0.001).
Furthermore novel object exploration time was decreased compared to the saline group after mPFC-infusion of SKF81297 at 0.025 μg/side (p<0.05) and 0.05 μg/side (p<0.05).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com