However, to exploit this approach may require the willingness to consider the possibility that drug targets might be addressed by molecules of rather low specificity and moderate potency.
Future screening and selection approaches can be envisioned to exploit this approach to optimize specific material functional features for both biopolymers and synthetic polymers in relation to sequence chemistry, a capability not currently available.
This current opinion review will focus on recent advances made in performing in vitro pathway-driven natural product diversification and opportunities for exploiting this approach for elucidating and entering this new chemical biology space.
We contend that by exploiting this approach further and examining genomes closer, one may gain a deeper understanding of our universal ancestor [47] and how the SGC could have originated.
Exploiting this approach by targeting DNA repair has emerged as a promising strategy for personalized cancer therapy.
More recently, two studies [120,121] exploited this approach to investigate the complexity of rat object recognition strategy.
Exploiting this approach, a 'domain grammar', (Dessailly et al., 2009) which exploits information from a protein domain resource, can be used to describe protein function.
To exploit this approach, however, constructing a large-scale database of the frequency distributions of STRs collected from a number of control samples is necessary.
We propose to exploit this approach, based on the search for nodes connected to AM mutated hubs, to discover new cancer biomarkers [ 22].
