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This design exploits the upregulation of GST in acute myeloid leukemia (AML) cells.
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Moreover, it is also becoming evident that mTOR signaling, which regulates an array of anabolic processes, including ribosome biogenesis, is often exploited by cancer cells to sustain proliferation through the upregulation of global protein synthesis.
Of note was the upregulation of EGR-1, previously found to be upregulated in the adipose tissue of FCHL patients, the upregulation of DCHR-7, the downregulation of LYPLA2, and the differential expression of several genes previously unrelated to FCHL.
Likewise, GW4869 prevented the upregulation of these miRs.
NF-κB signaling pathway mediates the upregulation of miR-200c-3p miR-200c-3p miR-200c-3p
Shedding is likely promoted by the upregulation of MMP14.
Moreover, the upregulation of OX40 gene expression coincided with the resolution of autoGVHD.
CHX treatment abrogated the Notch-dependent upregulation of HIF2α, whereas the upregulation of NRARP was unaffected by CHX (Fig. 2g, h), as expected.
The metabolic shift in this case is the upregulation of glycolysis.
CsA suppressed the upregulation of OX40 expression after allo-Ag in a dose-dependent manner.
He et al. reported that the upregulation of HSP70 expression activated cytotoxicity of CD8 T cells.
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