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This current opinion review will focus on recent advances made in performing in vitro pathway-driven natural product diversification and opportunities for exploiting this approach for elucidating and entering this new chemical biology space.
We contend that by exploiting this approach further and examining genomes closer, one may gain a deeper understanding of our universal ancestor [47] and how the SGC could have originated.
Exploiting this approach by targeting DNA repair has emerged as a promising strategy for personalized cancer therapy.
Exploiting this approach, a 'domain grammar', (Dessailly et al., 2009) which exploits information from a protein domain resource, can be used to describe protein function.
These were the first studies providing proof of concept of exploiting this approach of p53 activation as a potential cancer therapeutic.
By exploiting this approach, we sought to significantly improve our ability to analyze such "-omics" data sets comprehensively and systematically and, in turn, to minimize the introduction of personal bias.
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For example, in WLANs Multi-channel MAC (MMAC) protocol [9] exploits this approach whereas in case of CRNs Cognitive MAC (C-MAC) [10] uses similar frame structure.
However, to exploit this approach may require the willingness to consider the possibility that drug targets might be addressed by molecules of rather low specificity and moderate potency.
Future screening and selection approaches can be envisioned to exploit this approach to optimize specific material functional features for both biopolymers and synthetic polymers in relation to sequence chemistry, a capability not currently available.
More recently, two studies [120,121] exploited this approach to investigate the complexity of rat object recognition strategy.
To exploit this approach, however, constructing a large-scale database of the frequency distributions of STRs collected from a number of control samples is necessary.
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