We exploited the mouse model with conditional ablation of Fig4 in Schwann cells to investigate whether the resulting impairment of endolysosomal trafficking would influence myelin biogenesis during development.
Exploiting the knockout mouse resource the International Mouse Phenotyping Consortium (IMPC, http://www.mousephenotype.org/) has been established and funded to create mouse lines from each targeted ES cell and to determine the phenotype of the resulting mutant mice [ 9, 10].
Future studies, exploiting the transgenic MYCN mouse model TH-MYCN, a native neuroblastoma model in which tumorigenesis is driven by targeted expression of MYCN in the neural crest [46], would help understand the MYCN-CDKL5 relationship in the neuroblastoma pathogenesis, in vivo.
We monitored metastatic development in real-time exploiting the bioluminescence of mice bearing bone metastasis (ME), and of ME-treated groups.
In this study, we exploit the PDK1K465E/K465E mouse model to investigate how small changes in the activity of the Akt pathway impact on insulin resistance and tumorigenesis.
By exploiting the recently established haploid mouse embryonic stem cells (ESCs), we present an implementation of almost complete saturation mutagenesis in a mammalian system.
We tested the latter possibility by exploiting the fact that in mice, natural intra-specific IL4 variation clusters at the site 1 epitope for IL4Rα binding.
We then investigate the metabolism of 24S,25-epoxycholesterol 24S,25-epoxycholesterolerol 7α-hydroxylase knockout mouse (Cyp7by−/−).
Here, in this short article we summarise work conducted with rat models, and also discuss recent progress in exploiting the potential of genetically engineered mice.
In particular, the reductionist approach has been taken by exploiting the genetic homogeneity of inbred mice in which autoimmune arthritis can be induced by synchronised immunisation of groups of animals with single candidate joint autoantigens in adjuvants.
