Sentence examples for exploiting sequence from inspiring English sources
We show that highly selective PDE4B inhibitors can be designed by exploiting sequence differences outside the active site.
In this study, we designed a set of assemblage-specific primers by exploiting sequence variability in homologous genes from assemblages A, B and E. Primers were designed to amplify fragments of different size that generated different melting curves from each assemblage in real-time PCR (rt-PCR) experiments.
Moreover, it is a very simple method which is targeted at exploiting sequence information in the context of structural contacts.
Below, we will survey initial studies that analyse genome function exploiting sequence census methods, which will increasingly supersede microarray-based approaches.
By exploiting sequence evolutionary profile, the sensitivity of PSI-BLAST is substantially enhanced, with an overall performance nearly equivalent to the lapSVM classifiers (AUC = 0.823).
A comparative sequence analysis, exploiting sequence information from various resources, can be used to uncover hidden information, such as genetic variation.
Currently, several strategies exploiting sequence-specific endonucleases exist for purposeful genome editing, including Zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and the RNA-guided clustered regularly interspaced short palindromic repeats (CRISPR -Cas9 nuCRISPR -Cas9m [ 15].
Gaps between contigs were filled by exploiting sequences from overlapping BAC clones or by PCR.
Hidden Markov Model (HMM) for each of the 20 aaRS were constructed by the software package Sequence Alignment and Modeling System version 2.2.1 (SAM) [ 74] exploiting sequences in the aaRS database [ 75].
In this report, we have taken an approach for describing positioned nucleosomes, which exploits sequence information derived from the periodic occurrences of the 256 tetranucleotides in nucleosome DNA.
The first two software programs exploit sequence information together with structural information, whereas the last one only addresses sequence complementarity.
