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Intrigued by the hypothesis that a silencer favors the usage of the authentic 5′ss by down-regulating the cryptic one, we investigated its presence by exploiting natural models consisting of all missense mutations (c.135G>C, c.135G>T, c.137G>A, c.137G>C, c.138G>T, c.138G>C) (Fig. 2A) at the putative ESS sequence so far reported in moderate/severe HB patients (http://www.factorix.org).org
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This is the idea of the circular economy – an attempt to move away from our current 'take and dispose' approach to exploiting natural resources, which feeds an inefficient, linear model of resource consumption.
In recent years, upon increasingly exploiting natural sandstone, the natural ecology has been damaged severely.
"Most swimming techniques can be copied by exploiting natural vibrations of soft structures," says Valdivia Y Alvarado.
"Exploiting natural resources is capital intensive and does not create many jobs directly," he says.
Recent research has moved towards exploiting natural experiments, see Moffit (2014) for an overview.
Perhaps a more promising empirical strategy would be that of exploiting natural experiments.
Probes are introduced by exploiting natural cellular uptake processes (usually phagocytosis [10], [11], [12]).
We exploit natural stochastic motion models and controlled locomotion of biobots in conjunction with an aerial leader to explore and map a domain of interest.
This scientific principle has been validated repeatedly in the intervening years as investigators have described unique models that exploit natural differences in chemical and molecular structure, biochemical function, or physiological response between different cells, tissues, and organisms to address specific hypotheses.
We exploited natural genetic variation in the model plant Arabidopsis thaliana [25], [26], [27], [28].
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