Sentence examples for exploited the mouse from inspiring English sources

We exploited the mouse model with conditional ablation of Fig4 in Schwann cells to investigate whether the resulting impairment of endolysosomal trafficking would influence myelin biogenesis during development.

This work forms the basis for exploiting the mouse as a model in which to study mammographic density.

To further elucidate the function of Dnmt1 in aging and age-related diseases, we exploited the Dnmt1+/− mouse model to investigate how Dnmt1 haploinsufficiency impacts the aging process by assessing the changes of several major aging phenotypes.

We have exploited the fact that mouse GFP-talin1 can be used to rescue the talin1 knockdown phenotype in subconfluent HUVEC to carry out a comprehensive structure function study on talin1 in a cellular context (Fig. 7A).

To more directly determine the contribution of the lung-residing CD103+ and CD11bhi RDC subsets to the corresponding DC subsets accumulating in the MLN in response to respiratory virus infection, we exploited the transgenic (tg) mice expressing the non-human primate diphtheria toxin (DTx) receptor (DTR) driven off the murine CD11c promoter [33].

Exploiting the knockout mouse resource the International Mouse Phenotyping Consortium (IMPC, http://www.mousephenotype.org/) has been established and funded to create mouse lines from each targeted ES cell and to determine the phenotype of the resulting mutant mice [ 9, 10].

In this study, we exploit the PDK1K465E/K465E mouse model to investigate how small changes in the activity of the Akt pathway impact on insulin resistance and tumorigenesis.

To determine the levels of administered tumor suppressor miRNAs in mouse intestine, we exploited the fact that the synthesized miRNAs used in our experiment, like plant-produced miRNAs, are methylated at the 2′ position of the ribose of the 3′ terminal nucleotide, whereas endogenous mouse miRNAs are not.

To investigate the functional differences between the two isoforms of the ZFY genes in mice and humans, we exploited the fact that the acidic domains of Zfy2 and Zfx have been shown to activate transcription in the yeast Saccharomyces cerevisiae when fused to the DNA-binding domain of the Gal4 transcriptional activator (5).

My research has consistently exploited the fact that genes and whole chromosome regions are conserved between mouse and human.

For this purpose we improved and exploited the model of orthotopic PC-3 prostate tumors in nude mice.