Sentence examples for exploited in the synthesis from inspiring English sources

The transesterification activity of lipases has already been exploited in the synthesis and kinetic resolution of several compounds [10 12].

Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups, producing highly potent inhibitors with encouraging oral pharmacokinetic profiles and significant but sub-optimal anticoagulant activities.

Structure-based drug design was exploited in the synthesis of 3- 6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an alanylamide P4 group with acyclic tertiary amide termini.

Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activities and encouraging oral pharmacokinetic profiles.

Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa inhibitors, incorporating neutral and basic monoaryl P4 groups, ultimately producing potent inhibitors with effective levels of anticoagulant activity and extended oral pharmacokinetic profiles.

This fact, which is exploited in the synthesis for shape directing, is problematic within the exchange.

Ring closing metathesis methodology has been exploited in the syntheses of seven-membered rings.

The aldol reaction has, thus, been extremely widely exploited in the stereocontrolled synthesis of natural products and other complex bioactive small molecules [5].

Remarkably, the variant enzyme E192N had broad scope, and could be exploited in the parallel synthesis of a small library of sialic acid analogues of general structure 4 [55]; related compounds, such as 5, are potent and selective inhibitors of influenza A sialidase [56,57].

The ability of carboxylic acid derivatives to add to alkynes in the presence of gold(I) complexes was exploited in the first total synthesis of neurymenolide A (94) (Scheme 28) and in the synthesis of psymberin (97) (Scheme 29).

The strength of the XB interpenetrative assembly between the pyridine macrocycle and iodopyridinium thread was exploited in the RCM clipping synthesis of a novel [2]catenane by using a Grubbs catalyst.