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Mesenchymal stromal cells (MSC) have important immunomodulatory effects that can be exploited in the clinical setting, e.g. in patients suffering from graft-versus-host disease after allogeneic stem cell transplantation.
Along with microfilaments, intermediate filaments are the other component of the cytoskeleton that has yet to be exploited in the clinical setting.
Stem cell-derived vascular cells allow the generation of a greater number of ECs compared to mature sources that could be exploited in the clinical practice owing to their privileged immunogenic profile [19 21,33].
These approaches will also facilitate our understanding of the role of microRNAs in the development and progression of NPC and how these might be exploited in the clinical context (see the review by Bruce et al. [8]).
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Protein microarrays could be exploited in the screening [ 42].
Even if they are already being exploited in many clinical settings, the biological basis for the source and maintenance of their proliferation/differentiation potential after in vitro isolation and expansion needs further investigation.
The regulatory role of miRNA in tumor radiosensitivity will probably be exploited in clinical therapies in the near future.
Stem cell-based therapies, exploited in different clinical scenarios, have been recently the key matter of an important debate in the Italian as well as in the international scientific community due to the case of Stamina Foundation.
These are large scale medical taxonomies which have been exploited in modern clinical systems showing significant good results in the targeted clinical systems.
Overall, it is clear that MSCs exert immunosuppressive effects on several classes of lymphocytes through mechanisms that may be exploited in a clinical setting.
These data are promising and suggest that there is a critical role for the Fas death pathway in chemotherapy response which can be exploited in clinical practice to enhance the efficacy of chemotherapy in OS [ 40, 64, 65].
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