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This statement follows from our experience in creation and exploitation of the database TID2008 [41] (e.g., the difference equal to 3 dB for a given filtered image is easily recognized by any observer).
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In exploitation of this database we follow due to privacy regulations in Norway the principal of "If the data cannot travel to the algorithm, then the algorithm shall travel to the data".
Efficient exploitation of these databases is often hampered by a lack of appropriate tools, which allow easy and reliable identification of genes that miss functional characterization but are correlated with specific biological conditions (e.g. organotypic expression).
Our approach is based on the systematic exploitation of existing databases such as the UniGene database [ 23], which contain information about organ-specific expression patterns, applying a number of different filters.
Oncogenic gene fusion analysis is a growing field, made possible through the exploitation of large databases like TCGA.
The exploitation of EST databases to develop microsatellite markers was first attempted in rice [ 23] and has subsequently been reported from many other plant species [ 24].
These genomic resources have given rise to the first exploitation of EST databases for SNP discovery (unpublished data, Hayes et al).
To this end, the exploitation of the current wealth of 'omic'-scale databases can be facilitated by automated approaches, allowing researchers to directly address specific biological questions.
In addition, the web server David-WS enables the simultaneous exploitation of the enriched semantic terms given by all databases.
The categorical requirement for sound application and exploitation of such a database is high accuracy of both retention time and ion mobility for the identification of unknown signals [ 15].
Exploitation of the exponentially increasing amount of gene sequence data in public databases such as GenBank and recent EST projects is a very useful basis for identifying new polymorphic loci from the genomes of non-model organisms.
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