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However, empirical information is scarce on characteristic life history traits of exploiters and on the strategies allowing the successful exploitation of host resources.
Based on this, it has been proposed that viruses manipulate hosts through multifunctional proteins that facilitate exploitation of host resources and elicitation of specific changes in host phenotypes.
Moreover, the presented data support the concept of exploitation of host factors as suitable survival strategies.
Especially, sustained neutralization of C5a by exploitation of host immunity will be more optimal and cost effective for therapeutics.
Exploitation of host immune response to generate sustained C5a neutralizing antibodies without significantly compromising C5/C5b activity is a useful strategy for developing an effective vaccine for antibody mediated and C5a dependent inflammatory diseases.
Some genes, such as insulin-induced gene 1 protein (INSIG-1), cytosolic thyroid hormone binding protein and thyroid hormone receptor interactor 10, possibly associated with the exploitation of host hormones, could be modulated by S. japonicum miR-31 and miR-2d.
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Studies of gnathiid use of habitat, exploitation of hosts, and population dynamics have used various trap designs to estimate rates of gnathiid emergence, study sensory ecology, and identify host susceptibility.
So selection could raise the substitution rate in a wide variety of genes involved in successful exploitation of hosts, including genes that might be considered "house keeping genes" [ 5].
Most theory on the evolution of virulence is therefore based on two key assumptions: that disease severity increases with parasite exploitation of hosts, and that immunity acts solely to reduce parasite titres and the probability of death.
Our results may suggest that, in this system, evolution towards generalist exploitation of hosts with complex genetic architectures is more likely than the evolution towards increased specificity, thereby explaining the lack of clear-cut patterns of local adaptation.
Further studies of the interplay between EBI2 and EBV as well as EBV-encoded proteins could provide insight into the viral exploitation of the host organism and in particular the host immune system and also the immune response to viral diseases.
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