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Overall, this investigation reveals another mode of exploitation of cellular miRNA machinery by virus to their own advantage.
Hence, we have shown that HSV1 utilises membranes from the endocytic pathway for envelopment, revealing a new strategy for virus exploitation of cellular trafficking pathways.
These genes were mainly down-regulated (57 and 55%, respectively), and they reflect exploitation of cellular resources and/or suppression of defence responses during the compatible interaction.
Most of these genes peaked at 12~24 hpi, possibly reflecting the exploitation of cellular resources and/or the activation of defense responses [ 36, 31].
The most striking discovery in our investigation was that nearly 70% of the differentially-expressed grapevine genes we identified were downregulated during infection, possibly reflecting the exploitation of cellular resources and/or the suppression of defense responses [ 7].
The exploitation of cellular apoptotic pathways has been exhibited by many proteins encoded by IAV, such as PB1F2, NS1, M1, M2, and lately NP, all targeting strategic points in the host apoptotic pathway.
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This exploitation of the cellular endocytic trafficking machinery to release viral particles could lead to the identification of virus-specific modulators and provide opportunities to design new targeted anti-viral agents.
Exploitation of the cellular nuclear replication machinery by several DNA viruses is accompanied by alterations in the nuclear architecture and dynamics.
Successful gene therapy will require both rational vector development and exploitation of disease-specific cellular physiology to design targeted gene delivery vectors.
Concomitantly, the exploitation of high-throughput cellular data to support metabolic engineering has intensified in recent years [ 1, 2].
In addition, we discuss how the exploitation of the full potential of cellular immune interventions is influenced by regulatory frameworks.
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