Sentence examples for exploitable target from inspiring English sources

This metabolic difference represents an exploitable target for rational drug design.

This interdependence is an exploitable target for therapy to manage the chronic phase of disease and potentially prevent disease progression.

Assuming that such a proteomic feature might be an exploitable target of the virus, we hypothesized that proteins in rich clubs are preferably targeted by the pathogen.

SL metabolism is an exploitable target for the discovery of novel chemotherapeutics, and this target has been validated through the development of several sphingomimetics.

These data could serve as a useful compendium for integrated information on disease genes with the potential for exploring pharmaceutically exploitable targets.

As colonic expression of both Pept1 and Casr is relatively specific for L cells, and activation of both clearly stimulates hormone secretion, these pathways might offer exploitable targets for the mobilisation of intestinal GLP-1 and PYY.

Nevertheless, endogenous repair and regeneration happen during the secondary phase of SCI to minimize the extent of the lesion, reorganize blood supply through angiogenesis, clear cellular debris, reunite and remodel damaged neural circuits, and offer exploitable targets for therapeutic intervention [ 14, 15].

Understanding host- Mtb interactions and the biological mechanisms underlying our observations may reveal exploitable targets for future pharmaceutical and nutritional interventions that will improve care of people living with Mtb and HIV co-infection who are at risk of developing TB.

These data, together with the low incidence of hypoxia in physiologically normal tissues, mark tumour hypoxia as an attractive and exploitable therapeutic target.

For example, by next-generation sequencing of castrate-resistant prostate cancer (CRPC), Collins et al. [ 34] identified a homozygous 9p21 deletion spanning the MTAP, CDKN2, and ARF genes and deficiency of MTAP was suggested as an exploitable tumor target.

Current work focuses on identifying specific protein domains critical to the regulation of neuroblastoma cell motility and metastasis and on determining if these domains represent exploitable therapeutic targets.