Our study reveals an interesting regulation that could be exploited to activate human CPCs upon cardiac remodelling.
The conversion of 6 c through palladium-catalyzed allylation into 7 a or trifluoroborate[ 33] 7 b is notable for its use of KF (up to 4 equiv), which is also commonly exploited to activate ortho-silyl aryl triflates.
Similarly, identification of cancer-related gene products (eg enzymes) whose overexpression in tumors themselves or tumor vasculature could be exploited to activate MR, optical, or nuclear imaging probes (see [ 15, 16]) would be a significant addition to the cutting edge technologies described in the subsequent reviews.
Folate derivatization might therefore be exploited to target activated macrophages involved in inflammatory joint disease.
The UPR is activated in many human tumours and is a mechanism tumour cells exploit to survive hypoxia (Koumenis, 2006).
Consistent with this, we recently established that multiple members of the Arf family can recruit and activate the WRC (Koronakis et al., 2011), so this redundancy is likely exploited by Salmonella to activate WRC.
Tumor cells exploit HMGB1's ability to activate intracellular pathways that lead to cell growth and migration.
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For example, HIV, herpesviruses, hepatitis C virus, encephalomyocarditis virus, reovirus, dengue virus, West Nile virus, and herpes simplex virus have evolved strategies to activate and exploit NF-κB for optimal replication, or to control host cell proliferation and survival to maximize viral progeny production [ 6, 8, 17, 49, 50].
