Sentence examples for exploit this pathway from inspiring English sources

The co-inhibitory receptor Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) attenuates immune responses and prevent autoimmunity, however, tumors exploit this pathway to evade the host T-cell response.

This has raised interest to exploit this pathway to circumvent drug resistance.

Investigations of these key questions are essential to our ability to fully exploit this pathway for improving healthy aging, longevity, and associated drug development.

Despite a period of 70 years since the importance of testosterone in the control of PCa cells was first described, there is still much interest in how to exploit this pathway for the treatment of PCa.

The discovery that oestrogens are produced locally in breast tissues, by aromatisation of other sex steroid hormones [ 36], led to concerted efforts to exploit this pathway as a potential therapeutic target.

With FXIIa inhibitors currently under development [ 54], there may indeed be an opportunity to exploit this pathway as therapy of hypertension in otherwise difficult-to-treat conditions characterized by increased FXIIa in plasma, such as end-stage renal disease.

To exploit this internalization pathway and minimize the use of viral proteins, we developed a simple gene product that self assembles nanoparticles decorated with the knob domain of adenovirus serotype 5 fiber protein.

With this in mind, new drugs can be designed that exploit this reduction pathway by introducing an electron-withdrawing group adjacent to the reduction site when a reduction reaction is desired, or by adding an electron-donating group when minimization of the reduction pathway is desired.

New CRC treatment strategies could exploit this novel pathway potentially through the use of drugs that can only be activated by CYP2E1 or CYP1B1, and avoiding treatments that may be deactivated by these CYP450s.

It should also be highlighted that the mechanisms governing some of these Nrf2 regulatory pathways remain to be understood, but the knowledge of Nrf2 regulation will add to our understanding of Nrf2-mediated pathological states and how to exploit this critical protective pathway to prevent diseases or to treat diseases directly or in combination with other drugs.

Moreover, S. aureus infection exploits this PINK1-Fbxo15 patoway to impair mitochondrial integrity and produce lung injury.