Sentence examples for exploit the sequence from inspiring English sources

To exploit the sequence conservation information, WildSpan [ 34] (http://biominer.bime.ntu.edu.tw/wildspan/), which is developed to discover functional signatures and diagnostic patterns of proteins directly from a set of unaligned protein sequences, is incorporated.

For example, for non-coding regions, we could further exploit the sequence context of a variant to identify a possible functional element (e.g. a non-coding RNA site) and use this information to improve predictive accuracy.

On the other hand, methods such as BLAST and MEGAN [ 10] have tried to exploit the sequence homology but were inefficient as large portions of the reads fail to have a hit in the database.

"They've done something very creative," said William Haseltine, chief executive of Human Genome Sciences, the first company founded to exploit the sequencing of the human genome.

It is worth specifying that Pegasus reconstructs the fusion sequence exclusively on the basis of gene annotation and fusion breakpoint, and it does not exploit the sequenced reads because they are not an input to the program.

Exploiting the sequence difference (∼40%) between the two species of nematode, primers were designed and tested by the polymerase chain reaction (PCR) for their specificity using a panel of control DNA samples from common equid endoparasites, and from host tissues, faeces or muscid flies.

The procedure starts off by constructing an initial alignment exploiting the sequence information in a heuristic manner.

Thereby, Vorolign exploits the sequence similarity of the two proteins but does so in considering the residue contacts in the two structures.

The quest for assigning function to putative gene products exploits the sequence and structural similarities to known genes and further could be elucidated using molecular biology techniques [ 9, 10].

By exploiting the sequence data and considering the distribution of superfamily relatives on metabolic paths Thornton and co-workers showed [68] that the data supported a 'pathwork' theory of evolution, originally proposed by Horwitz et al.

Conventional sequence-based HLA typing approaches, the most recent of which exploits the sequence throughput of the Illumina MiSeq [ 8] and relatively long sequence reads of the 454 NGS platform [ 9], are targeted assays that rely on amplification of hypervariable sub-regions of these loci and variant detection within these amplicons.