Sentence examples for exploit linkage from inspiring English sources

The determination of the power of or of an appropriate sample size for genetic association studies that exploit linkage disequilibrium requires many assumptions.

When genotypes are missing, we exploit linkage disequilibrium in the local region to impute missing genotype calls using information from the neighbouring loci.

One reason for choosing a haplotype-level analysis, rather than a genotype-level one, is that in the presence of occasional genotyping failures the missing allele calls can be imputed by "borrowing strength" from information about the neighbouring loci, so as to exploit linkage disequilibrium over the studied DNA region.

With this haplotype-based approach, it is possible to simultaneously exploit linkage analysis and linkage disequilibrium.

Indirect association studies routinely exploit linkage disequilibrium around genes, particularly in isolated populations where it is assumed to be higher.

Methods that use population information are usually probabilistic or model-based and exploit linkage disequilibrium between close SNP by modeling haplotype frequencies.

Our tagging approach exploits linkage disequilibrium between single nucleotide polymorphism (SNPs) and the CD-associated HLA risk factors DQ2.5 and DQ8 that indicate direct risk, and DQA1*0201/DQB1*0202 (DQ2.2) and DQA1*0505/DQB1*0301 (DQ7) that attribute to the risk of DQ2.5 to CD.

Exploiting linkage disequilibrium between SNPs, we selected one SNP from each locus among those published.

Therefore, genomic selection mainly exploits linkage disequilibrium between SNPs and QTL [ 39].

QTL fine-mapping was performed using a previously described variance component approach that simultaneously exploits linkage and linkage disequilibrium [ 36].

Microsatellite studies exploited linkage relationships to create LD between the flanking sparse markers and a QTL within families, even when the marker was in linkage equilibrium with the QTL from a population perspective.