Cancer cells with BRCA mutations have deficiencies in homologous recombination, and drugs to exploit those deficiencies have been developed and used successfully in clinical trials.
Cognitive radio network (CRN) shows great promise to exploit these deficiencies by applying dynamic spectrum assignment.
More interestingly, we and others have recently shown that ATM loss can predict sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors, a novel drug that may exploit this deficiency, in breast cancer [ 35] as well as other cancers [ 19, 36, 37].
Cancers deficient in these genes are missing a key component of the double-strand break repair pathways necessary for error-free DNA repair, and treatment of cell lines or xenografts harboring defects in these genes with DNA crosslinking agents has proven a potent therapeutic option by exploiting these deficiencies [ 59- 62].
This has provided opportunities to exploit DNA repair deficiencies, whether acquired or inherited.
Here, we review efforts to exploit DNA repair deficiencies in tumors, with a focus on breast cancer.
In summary, our study demonstrated the oncolytic activity of RSV promotes selective apoptosis of androgen-sensitive and androgen-refractory prostate cancer cells by exploiting the deficiency in the antiviral signaling propagated by either the IFN-mediated JAK/STAT activation or NF-κB activation in virus infected cells.
Or the app might just be poorly designed, allowing hackers to exploit a security deficiency and insert malware on your phone when you visit a dodgy Web site or perhaps click on nefarious attachments or links in e-mails.
Our findings suggest that many of the newer therapies for BRCA1 breast cancers designed to exploit the BRCA1 deficiency in these cancers may also be effective in ER+ cancers that develop in this population.
The bioreductive drugs AZQ, mitomycin C and E09, however, have been developed to exploit the oxygen deficiency in the hypoxic fraction of solid tumors on the premise that hypoxic cells should show a greater propensity for reductive metabolism than well-oxygenated cells [ 2, 31- 33].
