Extending the concept of condition dependence, a series of studies have begun to analyze how immune activation affects gene expression regulation by explicitly perturbing primary cells in culture and then contrasting eQTL profiles with baseline [ 84– 86].
This result was expected as the mutation does not modify interactions present in the native state but was designed explicitly to perturb a hydrogen bond in the intermediate state.
Therefore, the most analogous parameters were perturbed: total species concentrations (where explicitly defined) or catalytic rate constants associated with production of a particular output.
When this system is perturbed by dissipative and excitation terms, which do not depend explicitly on time, we use planar Melnikov techniques to determine a parameter set which preserves the co-existence of both heteroclinicandhomoclinic orbits.
Third, this normalized-Hill approach does not explicitly incorporate competitive inhibition, leading to a small number of incorrect predictions when Gβγ was perturbed.
Effects of pollutant exposure on the thyroid gland, immune, cardiovascular and obesogenic systems have not been shown explicitly, in ruminants, but work on other species suggests that these systems can also be perturbed.
· Perturbed by punctuation?
