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Publicly promising such an explicit test for nominees -- and on the high-profile issue of campaign spending by big-money interests -- might normally attract a lot of attention.
As an explicit test for a genotype by-breeding experience interaction we compared the likelihood of this model to one in which rG was set to unity and VA was constrained to be constant across experience classes.
In addition, a more explicit test for the assumption of unidimensionality is undertaken.
Unlike these approaches, our method does not use a neutral model and therefore is not an explicit test for natural selection.
An explicit test for additive interaction (the full model including both additive and dominance effects plus interaction term versus reduced model that does not contain interaction terms) was performed on all possible SNP pairs among the top 10,000 SNPs, using two-marker analysis.
The comparison of M3 versus M0 is a test for variable rates of evolution, and not an explicit test for positive selection like the comparisons of M2a versus M1a and M8 versus M7, but may provide additional evidence for positive selection if the third category of sites has ω > 1.
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Explicit tests for gene-environment interactions were not performed.
Although explicit tests for positive selection proved negative, the power of such tests to detect positive selection where sequence variability is low is very limited and prone to false negatives (type 2 error) [45] [47].
Explicit tests for positive selection were also not significant.
The latter model permitted explicit testing for effects across time.
Replication studies and explicit testing for potential effect modification by diabetes in future analyses is required.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com