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In view of the poor prognosis of the patient group, there will be no explicit stopping rules based on the overall number of toxicities, since even high rates of reversible toxicities seem acceptable if there is a large survival gain.
There will be explicit stopping rules in place to terminate the trial early in the unlikely event that an unacceptably high rate of treatment related deaths (TRD) is observed.
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But what does seem clear is that the plunge was exacerbated by the markets' heavy reliance on computerized trades — both explicit "stop market" sell orders (that is, orders to sell a stock once it hit a certain price) and algorithmic trades that dictate buying and selling depending on different market factors.
One is an explicit "Stop Suggesting" feature, that lets you permanently switch off a recommendation for a show you really don't care about.
Dunovan et al. tested this model by asking human volunteers to complete two tasks where the decision to respond to a stimulus is made proactively using prior knowledge, or reactively using an explicit stop cue.
I founded Americans for Safe Access (ASA) in 2002, with the explicit goal of stopping federal raids and prosecutions of medical marijuana (cannabis) patients and their providers.
The answer to the primary research question was clear in 1993 and was the explicit reason for stopping the trial: it was improbable that a benefit from CEA prompted second-look surgery had been missed and in the absence of benefit there was net harm being done to the patients.
Another example (fortunately uncommon these days) would be music download services that allow you to purchase tracks but use copy protection with the explicit aim of stopping you from making copies.
It has nudity (including a glimpse of male frontal) and explicit sex that stops just short of pornography.
The strident feminism of Clarice's student years gives way to something less explicit, the characters stop flaunting thoughts about "liberty and equality for women".
Ali Parsa of the Circle Partnership, which manages the first big hospital within the NHS system to be run by a private firm, is upbeat: "I can't see anything explicit that would stop a private provider bidding to offer a service.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com