Strikingly, both clusters contain solutions with the C-terminus of site 1 Ub at close proximity to the Josephin active site, even though no explicit distance restraints were defined to position a Ub close to the active site of Josephin.
He preferred innuendo over the crudely explicit, a restraint that demanded some imagination from the audience and was the essence of his comedy.
Dennis Baker of The Guardian wrote that Barker "preferred innuendo over the crudely explicit, a restraint that demanded some imagination from the audience and was the essence of his comedy".
But officers were given explicit orders to use restraint, especially with live bullets.
Just as the display of affection has shifted from puritanical restraint to explicit display, humor is becoming freer and more adventurous in India.
They then completed the tasks in the following order: advert rating task (prime group only); food shopping questionnaire; size estimation task; food preferences task; and end of study questionnaire (including dietary restraint, and explicit attitudes to food).
A prior literature recommendation for the use of harder bond and geometry restraints that introduce explicit assumptions based upon theoretical values, such as the DFIX and FLAT directives in SHELXL, for the crystal sponges exists (Inokuma et al., 2014 ▶), and hard angular restraints (e.g., SHELXL DANG) might also be grouped in this category.
Writing well about sexual intercourse is not easy, and it has got more, not less, difficult as virtually all legal restraint on the explicit description of sexual acts in literature ceased in most western democracies from the 1960s onwards.
The Founders saw the abuse that a government can enact when it can obtain private information about citizens without restraint and included explicit checks on that power in the Fourth Amendment.
Iterative model building with COOT (Emsley and Cowtan, 2004) and refinement against the native data in PHENIX.refine (Adams et al., 2002) using explicit hydrogens and atom-level anisotropic restraints.
