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In a field that's long lacked an explanatory paradigm, one might expect a possible solution to get a warm reception.
If there is specifically a reduction in the incidence of bleeding ulcers, the results of the trial will strengthen an explanatory paradigm that suggests that the principal effect of low dose aspirin is an anti-haemostatic rather than an erosive one, requiring H. pylori infection for the development of an ulcer that bleeds because of impaired haemostasis.
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I haven't found a definitive answer, but I have several hypotheses that correspond to explanatory paradigms in the social sciences.
A number of mechanisms have been proposed to explain testosterone's neuroprotective effects related to the risk of developing AD [ 31], but there is a lack of explanatory paradigms to explain our findings.
For instance, explanatory paradigms such as life history theory, which postulates that the pressure of natural selection on survival falls after reproductive capacity has been reached, cannot adequately explain the aging of sterile worker honey bees.
It is also fundamental to the nature of science that all explanatory paradigms are subject to skeptical review, and that inquiry into a question is never "done" or "complete" (Lederman, 2007).
These texts instead presented individual experiments or thoughts that could be easily viewed as explanatory contributions to the current paradigm.
The substantial differences between explanatory and pragmatic trials illustrate a paradigm shift to clinical practice.
Since these other fields are the ones that actually produce economic activity, a serious interdisciplinary discussion over time could potentially lead to a new synthesis between economic theory and commercial practice and the emergence of a new, explanatory economic model to accompany the Third Industrial Revolution paradigm.
We need not (must not) cling to outdated and disproven concepts and paradigms when they have been shown to lack accuracy and explanatory power especially so when alternate new concepts and paradigms are formulated that provide a better objective fit with reality.
Such an adjustment, never easy, requires unprejudiced, honest assessment of the new realities with clear eyes, unencumbered by the defence of previously held paradigms that have lost any explanatory power.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com