We observed no obvious property of their DNA-contacting residues that strongly predicts success or failure and hypothesize that requirement for ligand binding, dimerization, cofactors, or protein modifications may represent other potential explanations for failures in heterologous assays.
Sometimes it's just better to find a home where good stuff happens, instead of sticking around a place where there's always an explanation for failure.
Instead, constraint on lysis interval, either absolute or due to pleiotropic effects on other phenotypes, seems the most likely explanation for failure to reach the predicted optimum.
Finding both alterations in different subclones and metastases of the same cancer, however, might provide an explanation for failure of anti-Her2 therapy in some cases.
Thus, an explanation for failure to report a hospitalization may have been the long recall period leading the patient to consider the visit as outside the specified period.
Indeed, the presence of KRAS-mutated CTCs in patients with KRAS wild-type primary colon carcinomas might be one explanation for failure of drug-mediated EGFR inhibition in these patients (Douillard et al, 2013; Peeters et al, 2013).
One might imagine a trivial explanation for failures to see Cpd I: proton-assisted decay of the hydroperoxoferric state occurs by protonation of the OOH- ligand and loss of H2O2, leaving a ferriheme product state.
One possible explanation for failures on MMF is the increased clearance suggested by the higher metabolite levels, as the MPAG/MPA C12 h ratio was significantly higher in patients who developed flares.
Explanations for the failure immediately surfaced.
But there are other explanations for his failure to find his daughter's body.
