On the basis of these indications, ORCHESTRA, together with the project ANTARES [3], has promoted the web site VEGA (http://www.vega-qsar.eu), which provides a highly detailed explanation on the analysis of model results for a given substance.
The review team hopes your manuscript will be able to move forward with improved analysis and better explanation of this analysis, without the need for new data.
2. Given that the authors are having trouble showing statistical significance for the dn/ds results, I'd assume the authors are using all the counts they can get; thus, some further explanation of limiting the analysis to "100 HA sequences" would be helpful.
A stronger explanation is needed as to what data was used to construct this figure and how it was utilized; We followed this request and have bolstered our explanation of this analysis in both the Results and discussion and Methods sections.
Here, we focus on the explanation of the enrichment analysis for Pathway.
A full explanation of the data analysis is included in the methods section.
Details of the formulas and an extended explanation of the statistical analysis can be found elsewhere [ 30].
An expanded explanation of the chemical analysis is provided in Additional files 1 and 2. Fish lines were maintained in the ALAAC accredited Smith College Zebrafish Facility using standard husbandry techniques ([ 125]; Zebrafish International Resource Center).
