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The architecture of working application with explanation of development decisions could help in developing new computer programs.

Whitman, Edmund Beecher Wilson, and others at the Marine Biological Laboratory in Woods Hole, Massachusetts, dedicated considerable energy to discovering the nature of each cell and its internal organization and relationships, in an attempt to discover the relative contributions of preformation and epigenetic development to a materialistic explanation of development.

RTM is thus not a mechanism, or an explanation of development.

(Morange 1997, p. 390) The roots of the crisis should be sought at the epistemological level: what molecular biologists cruelly lacked, what led them to a feeling of decadence, was the total absence of a definition of … what would be an explanation of development, [ … for this … ] required that another level of description of the biological facts not be discovered, but valorized.

As Morange notes, The roots of the crisis should be sought at the epistemological level: what molecular biologists cruelly lacked, what led them to a feeling of decadence, was the total absence of a definition of … what would be an explanation of development, [ … for this … ] required that another level of description of the biological facts not be discovered, but valorized.

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Keller finds explanations of development in terms of genes inadequate, because often the resulting cascades of molecular interactions are unknown; she even argues that "much of the theoretical work" in this area is "linguistic," depending on "ambiguity" and "novel metaphors".

Despite this predominance of genetic explanatory approaches and the frustration among researchers utilizing other approaches, a groundswell of interest has been building around physical explanations of development, especially in terms of their integration with genetic explanations (Miller and Davidson 2013).

More recently, there has been growing interest in physical explanations of development (Section 3.2) that involve appeals to mechanical forces due to the geometrical arrangements of mesoscale materials, such as fluid flow (Forgacs and Newman 2005).

It begs the question against those who maintain that some explanations of development must invoke higher level features to simply assert that the organismal context can always be molecularly described.

For example, Ernst Cassirer (1950, Part II), starting with Kant, explored reductionist themes related to causal explanations of development, including the debates about mechanism and vitalism surrounding Roux and Driesch, as well as the relations between physical science and biology.

Genetic explanations of development (Section 3.1), similar to what is seen in molecular genetics, work by identifying changes in the expression of genes and interactions among their RNA and protein products that lead to changes in the properties of morphological features during ontogeny (e.g., shape or size), while holding a variety of contextual variables fixed.

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