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As we discussed in the Explanation Generation section, the explanation generated by current ITS (Conati and VanLehn 1996; VanLehn et al. 2005; VanLehn and van de Sande 2009) does not focus much on modeling assumptions, or does so at most in an indirect/ad hoc way.
The procedure of the explanation generation is outlined in Fig. 3.
Automatic model generation by compositional modeling is not sufficient for automatic explanation generation in education.
However, this link plays an important role in explanation generation because it represents experts' insight "balance of forces is the dominant principle of the solution".
As discussed in the Explanation Generation section, experts first identify the dominant principle/law in solving a problem, then apply other principles/laws to derive its conditions.
The framework we propose makes it possible to systematically describe such knowledge, based on which the design of a set/sequence of problems and explanation generation for promoting conceptual understanding become possible.
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Despite the importance of immune system regulation with respect to pathogen defense, allergic reactions and autoimmunity, an explanation for the generation and maintenance of immune system activation and peripheral tolerance has remained elusive.
The most likely explanation for the generation mechanism of OwlAlp1 would be deletion of part of the OwlAlp2 sequence.
However, an explanation for the generation of a longer orfB transcript in sterile lines is yet to be offered.
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