It provides a mechanistic explanation for the developmental hourglass model in the dipteran lineage.
We conclude that XPO-1/CRM1 and CBC are required for the biogenesis of many C. elegans miRNAs, including let-7, providing a molecular explanation for the developmental phenotypes.
We have further observed that all three factors are important for the accumulation of miRNAs, including let-7, providing a molecular explanation for the developmental phenotypes.
Our study provides yet another explanation for the developmental discrepancy (Rafetseder & Perner, 2010; Rafetseder et al., 2010; Rafetseder et al., 2013).
Finally, quantitative system drift in early embryonic patterning networks, as reported here for the cyclorrhaphan gap gene system, provides an explanation for the developmental hourglass model (Seidel, 1960; Sander, 1983; Slack et al., 1993; Duboule, 1994; Raff, 1996).
The explanation for this may be developmental in nature skipping the five-digit stage may simply not be an option in tetrapods' developmental processes.
Explanations for these developmental changes seem to be found in the manner in which the individual solves a discrimination problem.
There are a number of plausible explanations for these developmental differences in functional activity within social brain regions.
Such models have shown to provide a fruitful approach for providing explanations for the developmental links between environmental factors confined to the domain of attachment and outcomes spread across a broad array of other domains, such as mental and even physical health [ 8].
One explanation for this pattern is that the developmental pathways that regulate production of the focal signal (and determine eyespot size; [ 50, 51, 63]) are much more flexible and more easily decoupled across a wing surface than the pathways that regulate the threshold level of response to signal concentrations (and determine eyespot color composition; [ 52, 53, 64, 65]).
