Sentence examples for explanation for the lifespan from inspiring English sources
One explanation for the lifespan enhancement by eRapa is that chronic mTOR inhibition delays the onset and growth of neoplasms.
It is possible secondary deleterious effects resulting from ubiquitous mild uncoupling activity may be overcoming any beneficial tissue-specific effects of decreased ROS production, providing an explanation for the lifespan effects.
Thus, a potential explanation for the shortened lifespan of daf-16 RNAi) daf-16 RNAinematodesve and heat-killed E. coni bothnot on other microorganisms is that the presence of certain microorganisms activates other signalive pandways that help extend the survival lifE.pan of the nematode.
A defining feature of both MEN1 and Li Fraumeni syndromes is the occurrence of multiple tumours, and a possible explanation for the decreased lifespan of the dual heterozygous animals compared to either of the individual lines may be increased overall tumour burden.
An obvious explanation for the reduced male lifespan on the poor quality diet is that the greater costs of providing the same sized nuptial gift in a poor quality environment are manifested as the reduced allocation of resources towards somatic maintenance and repair [49].
An alternative explanation for the changes in lifespan under stress in animals with altered corazonin neuronal function may be that secretion and/or expression of corazonin might be normally inhibited by stress, and the manipulations of corazonin neuronal excitability may either mimic or impede these normal actions of stress.
One possible explanation for the discrepancy between the lifespans of animals harboring sgk-1 loss-of-function mutations and animals subjected to sgk-1 RNAi is that strong loss-of-function mutations could cause developmental abnormalities that shorten adult lifespan by reducing general fitness; such abnormalities can be avoided by initiating RNAi during late larval or early adult stages.
As an example, the disposable soma theory also offers an explanation for lifespan extension by DR: when food is scarce, it is beneficial for the animal to use more energy for somatic maintenance and less for reproduction [ 106].
Alternatively, immunopathology could provide an explanation for the 'paradox of aging science' [40]: aging (i.e. reduction in maximum lifespan) is present in most species yet it directly opposes natural selection for maintenance systems.
