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Our findings provide a possible explanation for selection favouring accumulation of L1 elements on the X chromosome in placental mammals.
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However, based on the present study other explanations for selection pressures cannot be excluded since there may be a survival effect present for loneliness.
Previous biochemical and structural studies by us (Pugh et al, 2008a, 2008b; Honda et al, 2009) and others (Rudolf et al, 2006; Fan et al, 2008; Liu et al, 2008) suggested two mutually exclusive mechanistic explanations for selection of translocation polarity in SF2 helicases.
Finally we will provide a good theoretical explanation for the selection of the thresholds of the segmentation algorithm.
Where panelists selected "partly agree" or "disagree" for a statement, they were asked to provide a free-text explanation for their selection.
A possible explanation for the selection of initial and mean EVLWi as significant variables associated with prognosis may be an effect of the inclusion criteria used in those previous studies [12],[14],[16],[21], where ARDS was diagnosed on the basis of the AECC criteria [37].
Mayr's description builds an explanation for natural selection in a stepwise fashion, first establishing the potential of a mated pair of organisms to reproduce exponentially, then addressing the role of the environment in leading to differential survival and reproduction, and ultimately describing the process of speciation over long periods of time.
The likely explanation for the selection and maintenance of this strategy by CD8+ (and as our preliminary analysis suggests CD4+) T lymphocytes is the need to rapidly generate a large cohort of effector T cells directed to an invading pathogen from a very limited number of naïve pathogen-specific T cell precursors.
We also examined an alternative explanation for positive selection of 5' rare codon clusters.
The extreme dosage effects of the cluster in Drosophila melanogaster may be part of the explanation for the selection on synteny.
An alternate explanation to a purely immune explanation for positive selection on tachylectin-2 is that the protein may mediate a more general process of non-self recognition, limited not only to pathogen detection but also including symbiont identification.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com