While speculative, potential explanations for alteration of the relationship between FPG and A1C when FPG is >9.0 mmol/L can be proposed.
A possible explanation for these alterations may be a delayed emptying of the pancreatic outflow, not able to trigger pancreatitis but sufficient to induce a disorder of the normal pancreatic intracellular exocytosis process and, therefore, a leakage of pancreatic enzymes into the blood through the basolateral membrane of the acinar cell.
Thus, the most likely explanation for the alterations in granule morphology is that DFMO affects the process of dense core formation, independently of direct effects on serglycin.
SHB is a multifunctional adaptor protein potentially affecting numerous signaling pathways which were investigated in postnatal ovaries to obtain a mechanistic explanation for the alterations in follicle and oocyte development observed.
Hence, in muro changes are a more probable explanation for the alterations that were observed in the Vvpgip1 overexpressing lines.
In the Discussion, we suggest a possible explanation for these alterations in terms of perturbations in SAC self-avoidance, S/NSD, and synapse elimination.
Differences in inoculation route are also not an explanation for the alteration in ranking.
One possible explanation for the alteration in liver-associated proteins is the over-expression of interleukin-1 (IL-1) by white blood cells of horses with chronic laminitis (S. Steelman, unpublished observation).
The production of endotoxins by gram-negative bacterial was shown to decrease the activity of hepatic metabolism, the renal blood flow, and the glomerular filtration rate, and might be the explanation for the alteration of the drug elimination [ 20].
That said, in most cases, when asked by Mr. Marks, the companies had reasonable explanations for the alterations, usually related to the costs of raw materials.
