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The public is entitled to have a proper explanation derived, in the last resort, from competing tenders.
The first suggests an explanation derived from strategic level analysis.
The most parsimonious explanation derived from both the analysis of the PDZ domain tree and from the LIM domain tree is summarized in our model for the molecular evolution of the PDZ/LIM family (Fig. 6).
In contrast, the alternative explanation derived from the superposition hypothesis suggests that a given network always responds in a similar fashion (i.e. a transient response) and it is the rhythmicity of the stimulation that leads to the oscillatory components in the signal.
One likely explanation, derived from previous studies [ 18], is that the Russian-speaking women prevented unintended pregnancies by using less reliable contraceptive methods and, in contrast to Estonians, having an abortion increased the risk of them not using contraception in the future.
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The second explanation derives from the Red Queen Hypothesis, which posits an evolutionary arms race between predators and prey.
Another explanation derives "Pūtanā" from "Pūta" (purifying), thus meaning "she who purifies".
While the different methods used by the authors to quantify parasite movement could account for this discrepancy, another explanation derives from different potency and binding capacity of the inhibitors to P-gp, which is also suggested by the different reversibility of the compounds observed in replication and invasion assays.
A possible explanation derives from studies in weaver mice, in which only a single missense mutation in the pore region of the mouse Kcnj6 gene causes various aberrant changes in cerebellar granule cells [30], membrane permeability [31], loss of K+ selectivity [32], [33], significantly lower analgesia compared with wildtype mice [3], and lack of activating effects of ethanol [34].
The first explanation derives support from the facts that certain growth factors and inflammatory cytokines (such as IL-1 β, TNF α, PDGF, TGF β and heregulin- β1) can stimulate VEGF-C mRNA expression or protein synthesis in certain cells (Enholm et al, 1997; Ristimäki et al, 1998; Tsai et al, 2003), and that they can also upregulate COX-2 which is a cytokine-responsive gene (Ristimäki et al, 1994).
Here, we provide a detailed description of the correlations between SD and epilepsy, along with their putative mechanistic explanations derived from experimental studies in animals and humans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com