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What, then, explains the selectivity of love why I love some people and not others?
The first phosphorylation step, which is efficiently carried out only by thymidine kinases encoded by herpes viruses (and not by adenoviruses or other viruses), explains the selectivity of GCV for herpes virus-infected cells [ 33].
Thus, our finding that Src is overexpressed within stem and progenitor cells following Apc loss and during regeneration together with Src's requirement in both contexts explains the selectivity of Src for both regenerative and cancer cell proliferation.
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These free energy values could explain the selectivity of PAP channels to different dye molecules.
Baumli, S., Hole, A. J., Noble, M. E. M. & Endicott, J. A. The CDK9 C-helix exhibits conformational plasticity that may explain the selectivity of CAN508.
Molecular modeling studies were used to drive the design and X-ray crystallography studies were carried out to explain the selectivity of 3 for ADAM-10 over MMPs.
These pharmacophores explain the selectivity of binding to the MATs for various compound classes and have been used to search in silico databases for novel, potentially selective ligands.
The topological and electrostatic differences between the two protease binding sites also help explain the selectivity of non-covalent PLpro inhibitors.
Formation of an intermediate between the nitrocompound and the reduced form of the mediator is postulated to explain the selectivity of the reduction.
Comparison of ligand-free and ligand-bound proteasomes reveals conformational changes in the S1 pocket of β5c/X but not β5i, thereby explaining the selectivity of PR-957 for β5i.
A prominent hypothesis explaining the selectivity of Imatinib is that Abl has an intrinsic ability to adopt an inactive conformation (termed DFG-out), whereas c-Src appears to pay a high intrinsic energetic penalty for adopting this conformation, effectively excluding Imatinib from its ATP pocket.
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