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In addition, the substantial functional excess found in the extreme of the distributions of the statistics (particularly of non-synonymous SNPs) also points at positive selection as the most likely force for explaining this disproportion.
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DOI: http://dx.doi.org/10.7554/eLife.03251.020 10.7554/eLiFigure51.021 Figure 7. High cooperativity does not explain the disproportion between trans -SNARE interaction and fusion rate resulting from HOPS addition.
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