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This observation prompted us to investigate the possible role that X-inactivation plays in explaining this discordance.
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An alternative theory to explain this discordance is that the increase in expression of PPARγ mRNA when cells are treated with TGZ may increase the turnover and degradation of PPARγ protein thereby reducing protein expression.
Findings can explain this discordance.
There are at least three possibilities to explain this discordance.
We are uncertain on how to explain this discordance between datasets.
The definition of frailty attempts to explain this discordance, and to do so, researchers can apply different approaches.
For example, phenotypic mutation rates and genotypic mutation rates are dramatically different and genetics has been the primary molecular mechanism considered (Burger et al. 2006), but the inclusion of an additional mechanism such as epigenetics can help explain this discordance.
Hence, it is possible that many patients with COPD who have not been prescribed statins in observational studies are undertreated, a hypothesis suggested by STATCOPE investigators to explain this discordance.
This goes some way to explaining the discordance between reports of high job satisfaction in FDC[ 73] alongside workforce retention problems (pers comms, FDC educators, scheme management).
While SHM/CSR also occurs in most DLBCLs (explaining the discordance between percentage of MIB-1-positive and TK-1-positive cells in most DLBCL in our study), the relative contribution of DNA repair to 18 F-FLT uptake in DLBCL is apparently small in most cases, so that a significant correlation between percentage of MIB-1-positive cells and 18 F-FLT uptake can be found.
Potentially, the 3′ UTR lengths of NMD targeted transcripts in HeLa cells systematically differ from the annotated human genome reference set, explaining the discordance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com