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The unique helical hairpin of SNX5/6 is essential for binding, explaining the specificity of SNX5/6 for IncE.
Our experiments also suggest this epitope as highly immunogenic, thereby explaining the specificity of the immune response against this epitope in GRP78, observed in humans.
We thought that identification and analysis of critical functional residues at this site would aid in explaining the specificity of DDX3X- ATP binding site and designing of selective and efficient inhibitors that could result in inhibition of HIV-1 replication.
This residue is conserved in Lhca5 as well, but absent from Lhca1-3 sexplainingexplaining the specificity of the interaction.
This classical structure function paradigm has mainly been based on concepts explaining the specificity of enzymes, and on structures of folded proteins that have been determined primarily using X-ray diffraction on protein crystals.
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The low amino acid sequence similarity between TRDs explains the specificity of a particular MTase for a specific sequence [9].
This may explain the specificity of AF pathway extrolite profiles (chemotypes) for specific Aspergillus taxa.
It is probable that stathmin levels and activity are regulated according to the demands of each specific cell type and this could explain the specificity of clinical manifestations in different motor neuron diseases.
The comparison of the structures between MAOA and MAOB clearly explains the specificity of clorgyline for MAOA inhibition.
The structure explains the specificity of the antibody for intact ampicillin and the degree of cross-reactivity of aL2 with a wide variety of ampicillin analogs.
Gradual changes in extracellular potassium concentration may also contribute to the slow integrative process preceding barrage firing, but direct depolarization of interneuron axons cannot fully explain it, as this mechanism cannot explain the specificity of barrage firing to NPY interneurons.
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