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While extensive biochemical investigations on the interaction of AHR with ligands have been carried out, studies comparing the abilities of specific computational algorithms in explaining the potency of known AHR ligands are lacking.
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Perhaps only Christopher Booker's enthralling The Seven Basic Plots could explain the potency of this appeal.
This combination of lethal effects explains the potency of these peptides, which are active in nanomolar concentration.
The inhibitor appears to mimic the substrate transition state, which may help explain the potency of this inhibitor and the catalytic mechanism of pyrimidine nucleotide phosphorylases (PYNPs).
These connections may help to explain the potency of activated RasV12 and YAP in transformation.
Based on structural analysis with GlcNAcstatin C [ 41] and GlcNAcstatin D in complex with CpOGA we can explain the potency of this inhibitor family.
This explains the potency of this regimen in NSCLC, but clearly resistant patients exist, and indeed some tumors in this study were more sensitive to alternative regimens.
This combination of roles may also explain the potency of mammalian YAP in control of tissue growth and its ability to induce cancer when overexpressed (Dong et al., 2007; Pan, 2010).
Simultaneously inhibiting ATP production and Hsp90 chaperone activity may explain the potency of cruentaren A among the many different cancer cell lines and provides a novel approach to modulating the Hsp90 protein folding machinery.
Further understanding of bisphosphonate interaction with FPPS aids in explaining the clinical potency of the bisphosphonates.
This peak could be identified by its retention time and its UV spectrum as compound 15 indicating that compound 10 is rapidly converted to the highly active compound 15 in planta and explaining the different potency of compound 10 in vitro and in vivo.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com