A subsequent study in 2004 [7], found that the evidence for a single major gene affecting the condition was not conclusive despite a heritability estimate for the phenotype of 0.73, and that this model did not completely explain the inheritance of inherited deafness in this breed.
Darwin claimed that gemmules were produced throughout the body in order to explain the inheritance of acquired characteristics.
But in another sense Darwin is opposed to modern cultural evolutionists, for rather than distinguishing between different interacting inheritance systems (e.g. cultural and genetic inheritance), Darwin tends to use the transmission of gemmules to explain the inheritance of all types of trait.
Usually, genome-wide association studies (GWAS) of traits of economic interest using high-density single nucleotide polymorphism (SNP) panels aim at identifying regions that can explain the inheritance of the traits [ 14].
Consequently, initial hopes that the identification of a small number of SNPs would explain the inheritance of CVD and other diseases and serve as predictors, similarly to classical Mendelian inheritance, have not been realized, because this is not the aim of GWAS.
The formation of biaxially oriented polycrystals can be explained by the inheritance of octahedral TiO6 blocks from the layered to regular perovskites.
Within this context metamorphism during the early stages of orogenesis can be explained by the inheritance of elevated geothermal gradients produced by lithospheric thinning and sediment loading during formation of the basin.
Our findings are consistent with both loss- and gain-of-function disorders among the PCP mutants, and suggest that the wide range of NTD-like phenotypes that are associated with human PCP mutations might be explained by the inheritance of different combinations of mutant alleles in different individuals.
In 1916 another student of Morgan's, Calvin Bridges, used fruit flies with an extra chromosome to prove beyond reasonable doubt that the only way to explain the abnormal inheritance of certain genes was if they were part of the extra chromosome.
This observation could be explained by either the inheritance of genes that limit fetal growth, such as is described in the fetal insulin hypothesis, or fetal adaptations in response to relative malnutrition in utero (the thrifty phenotype [ 18]).
