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ALOX12 might be one of the factors explaining the high risk of colorectal cancer in patients with schizophrenia.
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Because populations with high testicular cancer risk also have lower maternal testosterone, we suggest that testosterone could play a role in explaining the higher risk of son's testicular cancer among mothers who drank alcohol during pregnancy.
Little is known about the role of obesity in explaining the higher risk of stillbirth observed in Black and South Asian women in the UK, although there is evidence from other high income countries that the association between obesity and obstetric outcomes varies by ethnicity [ 14, 15].
This possibility might explain the high risk of infections found in patients with CCL [ 87].
A broad range of traditional risk factors could not fully explain the high risk of mortality in such population [ 4].
Our findings may partly explain the high risk of tachyarrhythmia in patients who have undergone cardiac surgery.
The feeding of the system by endogenous ACh would explain the high risk of tumorogenesis that former smoker show after smoking cessation for long time.
The direct link between diabetes and cancer through hyperinsulinemia, hyperglycemia and inflammation may explain the high risk of cancers in prevalent T2DM patients than in those newly-diagnosed.
Theories linking malaria to iNTS disease in children do not readily explain the high risk of disease in neonates who do not often get malaria.
One hypothesis that might explain the high risk of gastric cancer associated with alcohol in Lithuania is the presence of contaminants, e.g. acetaldehyde, which has been classified as carcinogenic to humans (Group 1) [ 4, 21, 42].
These factors may explain the high risk of MDR-TB among TB patients, particularly in countries of the former Soviet Union, where anti-TB drug shortages and a disruption in healthcare services characterised the early years following their independence over two decades ago [ 20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com