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In any case, with both clocks, a Beringian stage preceeding the expansion into the Americas – estimated at slightly different starting times and with a different duration depending on the clock employed – most likely took place, thus explaining the differentiation of the pan-American lineages from the Asian sister-clades (Figure 1).
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Professional antigen presenting cells, however, were not present in the OP9-dl1 cultures or in 2-deoxyguanosine-pretreated FTOCs, which may explain the differentiation of thymocytes in vitro but not in vivo.
Therefore, the use of raw accelerometry may explain the differentiation of sedentary behaviour from low-intensity PA in this study.
This selective assembly of signalling complexes may help cells to distinguish different stimuli and may explain the differentiation of the specific downstream responses of these pathways.
Reciprocally, informal discussions suggest that farmers from ZS3 regularly renew their seeds from the much lower altitude zone ZS6 following crop failures in cold years: such preferential exchanges might explain the differentiation of these two zones relative to the others.
P. t. ellioti and P. t. troglodytes appear to be characterized by a pattern of isolation-with-migration, and thus, we propose that neutral processes alone can not explain the differentiation of P. t. ellioti and P. t. troglodytes.
As they are important in cell-cell signalling as well as the regulation of pathogenicity factors and biofilm formation (i.e. they exist at the crossroads of sensing and gene expression), the rpf genes and their regulation targets that contain SNPs are good candidate genes to explain the differentiation of the pathotypes in terms of their virulence and host range.
The heterogeneity in protein abundance may be one of the reasons to explain the differentiation preference of HSCs for the erythroid lineage or the myeloid lineage.
However, absence of Sox9 cannot explain the differentiation defect in SoxB1-deficient oligodendrocytes (Finzsch et al., 2008).
It could be explained by the differentiation of salinity, with high salinity (open sea) and low salinity (lagoon).
This protective effect may be explained by the differentiation of breast tissues induced by a full-term pregnancy, resulting in lower susceptibility to carcinogenic influences [ 1].
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