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Structural haplotypes across the DEFA1A3 locus indicate that intra-allelic rearrangement is the predominant mechanism responsible for changes in DEFA1A3 copy number, explaining the conservation of linkage disequilibrium across the locus.
This headlong erasing-all-traces-of-the-past phase would have eased up before the born-again genes began their inter-viral odyssey, explaining the "conservation of the hallmark proteins in extremely diverse classes of viruses with widely different replication/expression strategies".
However, our computer simulations show that the correlation strengths are much higher for clusters including OBP than for random groups of 31 comparable clusters (P < 1e−5 and P = 0.010; fig. 4 C and D for the TE chromatin state and for JIL-1), which suggests that the JIL-1 binding intensity and TE chromatin state are relevant factors explaining the conservation of clusters including OBP genes.
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The sequence of this loop appears extremely conserved within Staphylococcaceae SRP sRNAs, and also well conserved in the Firmicutes phylum, indicating a common evolution which explains the conservation of the loop structure.
This finding explains the conservation of the axoneme-specific sequence motif through 1.5 billion years of evolution.
Immigration and short time elapsed since outbreaks could explain the conservation of genetic diversity after the demographic crash.
Although speculative, this perhaps explains the conservation of Asp-55 and Asp-56 along with Asp-57 (Fig. 6b).
According to our model of cis-regulated alternative splicing, splicing variants would be kept in the population due to balancing selection acting on tissue-specific variants, which would explain the conservation of the splicing status between human and mice.
This second phase of evolution explains the conservation of the new surfaces among Mecopterida species.
The imprinting of Pdcd2 and neighboring loci could explain the conservation of the synteny.
On one hand, they suggest that coexpression per se cannot explain the conservation of bipromoter structures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com