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Undoubtedly, there is still an uncertainty regarding the mechanism explaining the activity of UCP2 and other novel UCPs [47] and in the present study we did not investigate the precise mechanism allowing UCP2 to inhibit insulin secretion.
The statistical framework we have used to address this hypothesis (described in detail in the methods section) relies on a regression model explaining the activity of a given pathway (which we remind is the first or second principal component computed from the gene expression matrix associated to a given pathway) as a linear combination of three chemical features.
Similar(58)
A leaflet explaining the activities of I.C.E.R.C.
We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties.
Lipophilicity was shown not to be relevant to explain the activity of these derivatives, whereas shorter N N distances and lengthy substituents lead to more active compounds.
Certainly, the brain has many more different types of cell in it than any other organ.A similar idea about generating variation has been proposed in the past, to explain the activity of LINE-1 elements in sex cells.
The light provided by a full moon – some 12 to 16 times greater on cloudless nights than at other lunar phases – may also explain the activity of wolves and other predators.
A combination of landscape scale, local, and seasonal effects explained the activity of most of the investigated bats.
The approach we used in this study relies on the use of logistic regression to model how the scores issued by virtual screening methods explain the activity of the compounds in a virtual screening experiment.
This behavior, which was also obtained in[11], is here confirmed; this is further evidence that the BET alone cannot explain the activity of the soot oxidation catalytic reaction and that the contact between soot and the catalyst should be promoted.
First, Leibniz moves rather quickly from a conceptual explanation of substance in terms of the complete concept theory, to the conclusion that this consideration is sufficient to explain the activity of concrete substances.
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CEO of Professional Science Editing for Scientists @ prosciediting.com