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Atomistic-scale understanding of topotecan interactions with the DNA-enzyme complex is fundamental to the explaining of its poisonous effect and of the drug resistance observed in several single residue topoisomerase mutants.
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"VRI's Threat, Risk and Vulnerability Assessments focus on safety and value and address a full spectrum of physical security, integrity, intellectual property and other operational risks," VRI explains of its work on its website.
On multivariate regression (age and sex-adjusted) CRP and HbA1c were significant independent predictors of fibrinogen, explaining 27% of its variance; CRP alone explained 25% of fibrinogen variance.
These ranged from explaining no variation in an alternate family to explaining 38% of its PHT variation.
Substantial genetic influences were found for Nonverbal Cognitive Ability, explaining 70% of its variance.
PeakVO2 was significantly related to gender, ambulatory status and muscle strength, explaining 55% of its variance.
Age and SBP were retained as the independent predictors of E-to-e′ ratio, explaining 8.3% of its variation.
For POS, the exploratory factor analysis grouped the 10 POS items in four factors explaining 67% of its variability.
In the whole population, 1-h postload glucose was the major predictor of LVMI, explaining 8.9% of its variation (P < 0.0001).
In exploratory analysis of individual means, three out of the five factors in the EQoL explained 75% of its variability, four out of the 10 factors in POS explained 63% of its variability, and in the Hope Index, nine out of the 12 items explained 69% of its variability.
Self-interest explains much of its impact.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com