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Results were used in to identify codons most enriched in the evolution, and thus most critical for explaining expression.
Stochastic or genetic background-based epigenetic changes may be a superimposed regulatory element explaining expression differences.
However, instead of explaining expression similarity with cis-regulatory descriptors, transcription factors were found whose joint expression pattern was concordant with that of a cluster of genes.
In the context of previous methods explaining expression clusters with cis-regulatory information, the novelty of our work chiefly consists in a model-based treatment of the dynamical gene expressions.
However, recent studies demonstrate a significant role of chromatin structure in explaining expression divergences between duplicated genes (Li et al. 2010) and the evolution of gene regulation (Tsankov et al. 2010) in yeast.
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The results, shown in Figure 6, indicate that models including the 'visit' predictor perform significantly better than models without 'visit,' confirming the central importance of direct experience with a city in explaining expressions of fear when that city is attacked.
Common TFBS modules could partly explain expression similarity of the ZNF genes.
The detected eQTLs for global MZDE genes well explained expression variations across RILs, 86 % on average.
This could partly explain expression similarity, but regulatory elements from outside the proximal promoter regions might also contribute.
It was reported previously that life-history variation governed by natural selection explains expression variation of 22% genes in marine species (Whitehead & Crawford, 2006b).
Another approach has constructed causal graphs from curated interactions in literature and used these graphs to explain expression profiles (Chindelevitch et al., 2012).
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CEO of Professional Science Editing for Scientists @ prosciediting.com