Therefore, it is logical to explain the requirement of NADPH of TcAAD to catalyze reduction reactions at pH 6.0.
In the 2D plot, HPr was found in four distinct clusters (Fig. 4B), thus explaining the requirement of four conformers in the ensemble.
The pseudoknot stabilization by magnesium, in combination with P1 stabilization by SAM, explains the requirement of both SAM and magnesium to form the fully collapsed metabolite-bound closed state of the SAM-I riboswitch.
Lets us explain the requirement of three or more insurers ((Mge 3)) through an example of profitable deviations with two insurers that are ruled out with three insurers and easy to generalize for (M>3).20 If there are only two insurers ((M=2)), the RS equilibrium is not robust to a deviation by the insurer offering the contract (L^{RS}).
While any of these explanations may be true, none of them would explain the requirement of dopamine receptors for the appetitive paradigm.
These results explain the requirement of ectoderm for morphological somite formation [34], [35] and demonstrate that FN needs to be assembled into a matrix in order to support somitogenesis.
The extent of global regulation of translation is much greater than previously thought [10], with profound effects in all stages of Salmonella's life cycle including a variety of house keeping pathways and known and novel virulence factors, in part explaining the requirement of both translational regulators for virulence in Salmonella.
We show that a single point mutation at the TMD of Sx 1A, C271V (CC/VC) or C272V (CC/CV), disrupted voltage-evoked secretion, and propose a model to explain the requirement of the two TMD vicinal cysteines for supporting the secretion process.
Since the expression of MBD2 would be dependent on HDAC activities, our above results would potentially explain the requirement of HDAC inhibitors in order to effectively modulate corepressors binding and to maximally restore the reexpression of Nrf2 as well as induction of NQO1 in TRAMP C1 cells.
At least two alternative models can be put forward to explain the requirement of α-importin: either bona fide interaction of PB2 with α-importin is necessary for the proper folding of an active viral polymerase complex or it is needed for RNP replication itself.
